Anthony Joshua lost his IBF, WBA, and WBO championships in a thrilling battle at Tottenham Hotspur Stadium on Saturday night.
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Usyk won a unanimous decision over Joshua.
117-112, 116-112, and 115-113 were the judges’ scores.
Joshua was saved by the bell, but the Ukrainian’s quickness and technique were too much for him.
Joshua was badly damaged in the third round and ended the bout with a swelling injury to his right eye.
This is his second career loss, following a loss against Andy Ruiz Jr in 2019.
The loss tonight has thrown a kink in the works of an undisputed title match between Tyson Fury and Deontay Wilder, who fights again on October 9.
Usyk joins Evander Holyfield and David Haye as the only boxers to win world titles at cruiserweight and heavyweight.